PDBe 2sqc

X-ray diffraction
2Å resolution

SQUALENE-HOPENE CYCLASE FROM ALICYCLOBACILLUS ACIDOCALDARIUS

Released:

Function and Biology Details

Reactions catalysed:
Squalene = hop-22(29)-ene. 
Hopan-22-ol = squalene + H(2)O. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Squalene--hopene cyclase Chains: A, B
Molecule details ›
Chains: A, B
Length: 631 amino acids
Theoretical weight: 71.62 KDa
Source organism: Alicyclobacillus acidocaldarius
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: P33247 (Residues: 1-631; Coverage: 100%)
Gene names: Aaci_2443, shc
Sequence domains:
Structure domains: Glycosyltransferase

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P43212
Unit cell:
a: 118.82Å b: 118.82Å c: 276.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.153 0.153 0.187
Expression system: Escherichia coli K-12