PDBe 2shp

X-ray diffraction
2Å resolution

TYROSINE PHOSPHATASE SHP-2

Released:
Source organism: Homo sapiens
Primary publication:
Crystal structure of the tyrosine phosphatase SHP-2.
Cell 92 441-50 (1998)
PMID: 9491886

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 11 Chains: A, B
Molecule details ›
Chains: A, B
Length: 525 amino acids
Theoretical weight: 60.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q06124 (Residues: 1-529; Coverage: 88%)
  • Best match: Q06124-3 (Residues: 1-459)
Gene names: PTP2C, PTPN11, SHPTP2
Sequence domains: SH2 domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P21
Unit cell:
a: 45.9Å b: 214.5Å c: 55.7Å
α: 90° β: 96.3° γ: 90°
R-values:
R R work R free
0.199 0.199 0.27
Expression system: Escherichia coli