PDBe 2rol

Solution NMR

Structural Basis of PxxDY motif recognition in SH3 binding


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Epidermal growth factor receptor kinase substrate 8-like protein 1 Chain: A
Molecule details ›
Chain: A
Length: 64 amino acids
Theoretical weight: 7.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q8TE68 (Residues: 478-537; Coverage: 8%)
Gene names: DRC3, EPS8L1, EPS8R1, PP10566
Sequence domains: SH3 domain
Structure domains: SH3 Domains
T-cell surface glycoprotein CD3 epsilon chain Chain: B
Molecule details ›
Chain: B
Length: 12 amino acids
Theoretical weight: 1.39 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: P07766 (Residues: 181-192; Coverage: 7%)
Gene names: CD3E, T3E

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 84%
Refinement method: torsion angle dynamics
Chemical shifts: BMR11040  
Expression systems:
  • Escherichia coli
  • Not provided