PDBe 2rmc

X-ray diffraction
1.64Å resolution

Crystal structure of murine cyclophilin C complexed with immunosuppressive drug cyclosporin A

Released:
Primary publication:
Crystal structure of murine cyclophilin C complexed with immunosuppressive drug cyclosporin A.
Proc. Natl. Acad. Sci. U.S.A. 90 11850-4 (1993)
PMID: 8265636

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
CYCLOSPORIN A Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 11 amino acids
Theoretical weight: 1.22 KDa
Source organism: Tolypocladium inflatum
Expression system: Not provided
Peptidyl-prolyl cis-trans isomerase C Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 182 amino acids
Theoretical weight: 19.94 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: P30412 (Residues: 31-212; Coverage: 86%)
Gene names: Cypc, Ppic
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like

Ligands and Environments

No bound ligands

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21
Unit cell:
a: 60.3Å b: 74Å c: 97.9Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.197 not available
Expression system: Not provided