PDBe 2rma

X-ray diffraction
2.1Å resolution

Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero 20-mer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
CYCLOSPORIN A Chains: B, D, F, H, J, L, N, P, R, T
Molecule details ›
Chains: B, D, F, H, J, L, N, P, R, T
Length: 11 amino acids
Theoretical weight: 1.22 KDa
Source organism: Tolypocladium inflatum
Expression system: Not provided
Peptidyl-prolyl cis-trans isomerase A Chains: A, C, E, G, I, K, M, O, Q, S
Molecule details ›
Chains: A, C, E, G, I, K, M, O, Q, S
Length: 165 amino acids
Theoretical weight: 18.04 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P62937 (Residues: 1-165; Coverage: 100%)
Gene names: CYPA, PPIA
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like

Ligands and Environments

No bound ligands

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21
Unit cell:
a: 72.6Å b: 160.9Å c: 95.3Å
α: 90° β: 90.6° γ: 90°
R-values:
R R work R free
0.17 0.17 not available
Expression system: Not provided