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Crystal structure of PHD finger-linker-bromodomain Y17E mutant from human BPTF in the H3(1-9)K4ME2 bound state

X-ray diffraction
1.45Å resolution
PDB entry 2ri7 coloured by chain, front view.
PDB entry 2ri7 coloured by chain, side view.
PDB entry 2ri7 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Histone H3.1 and Nucleosome-remodeling factor subunit BPTF
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Multimeric state: hetero dimer
Accessible surface area: 10884.51 Å2
Buried surface area: 1462.3 Å2
Dissociation area: 516.49 Å2
Dissociation energy (ΔGdiss): -0.03 kcal/mol
Dissociation entropy (TΔSdiss): 6.37 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-159403

Macromolecules

Nucleosome-remodeling factor subunit BPTF
Chain: A
Length: 174 amino acids
Theoretical weight: 20.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q12830 (Residues: 2865-3033; Coverage: 6%)
Gene names: BPTF, FAC1, FALZ
Pfam:
InterPro:
CATH:
Nucleosome-remodeling factor subunit BPTF in PDB entry 2ri7, assembly 1, front view.
Nucleosome-remodeling factor subunit BPTF in PDB entry 2ri7, assembly 1, side view.
Nucleosome-remodeling factor subunit BPTF in PDB entry 2ri7, assembly 1, top view.
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Histone H3.1
Chain: P
Length: 9 amino acids
Theoretical weight: 1.09 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P68431 (Residues: 2-10; Coverage: 7%)
Gene names: H3C1, H3C10, H3C11, H3C12, H3C2, H3C3, H3C4, H3C6, H3C7, H3C8, H3FA, H3FB, H3FC HIST1H3C, H3FD, H3FF, H3FH, H3FI, H3FJ, H3FK, H3FL, HIST1H3A, HIST1H3B, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J
Histone H3.1 in PDB entry 2ri7, assembly 1, front view.
Histone H3.1 in PDB entry 2ri7, assembly 1, side view.
Histone H3.1 in PDB entry 2ri7, assembly 1, top view.
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