Function and Biology Details
Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
- not assigned
Structure analysis Details
Assemblies composition:
Assembly name:
PDBe Complex ID:
PDB-CPX-132685 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Epidermal growth factor receptor
Molecule details ›
Chains: A, B, C, D
Length: 324 amino acids
Theoretical weight: 36.97 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:
Length: 324 amino acids
Theoretical weight: 36.97 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
P00533 (Residues: 702-1022; Coverage: 27%)
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:
ERBB receptor feedback inhibitor 1
Molecule details ›
Chains: E, F
Length: 40 amino acids
Theoretical weight: 4.25 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Sequence domains: EGFR receptor inhibitor Mig-6
Length: 40 amino acids
Theoretical weight: 4.25 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: Q9UJM3 (Residues: 325-364; Coverage: 9%)
Sequence domains: EGFR receptor inhibitor Mig-6
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
ALS BEAMLINE 12.3.1
Spacegroup:
P21
Expression systems:
- Spodoptera frugiperda
- Not provided
