PDBe 2rd0

X-ray diffraction
3.05Å resolution

Structure of a human p110alpha/p85alpha complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Phosphatidylinositol 3-kinase regulatory subunit alpha Chain: B
Molecule details ›
Chain: B
Length: 279 amino acids
Theoretical weight: 33.67 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P27986 (Residues: 322-600; Coverage: 39%)
Gene names: GRB1, PIK3R1
Sequence domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P212121
Unit cell:
a: 115.058Å b: 117.05Å c: 151.584Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.267 0.263 0.323
Expression system: Spodoptera frugiperda