PDBe 2rc4

X-ray diffraction
3Å resolution

Crystal Structure of the HAT domain of the human MOZ protein

Released:

Function and Biology Details

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone acetyltransferase KAT6A Chain: A
Molecule details ›
Chain: A
Length: 287 amino acids
Theoretical weight: 34.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92794 (Residues: 501-784; Coverage: 14%)
Gene names: KAT6A, MOZ, MYST3, RUNXBP2, ZNF220
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand ACO 1 x ACO
1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM, null
Spacegroup: I422
Unit cell:
a: 109.2Å b: 109.2Å c: 144.779Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.277 0.276 0.283
Expression system: Escherichia coli