PDBe 2r9s

X-ray diffraction
2.4Å resolution

c-Jun N-terminal Kinase 3 with 3,5-Disubstituted Quinoline inhibitor

Released:
Source organism: Homo sapiens
Primary publication:
3,5-Disubstituted quinolines as novel c-Jun N-terminal kinase inhibitors.
Bioorg. Med. Chem. Lett. 17 6378-82 (2007)
PMID: 17911023

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 10 Chains: A, B
Molecule details ›
Chains: A, B
Length: 356 amino acids
Theoretical weight: 41.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P53779 (Residues: 46-401; Coverage: 77%)
Gene names: JNK3, JNK3A, MAPK10, PRKM10, SAPK1B
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments


1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P212121
Unit cell:
a: 68.318Å b: 81.344Å c: 123.76Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.205 0.29
Expression system: Escherichia coli BL21(DE3)