PDBe 2r4r

X-ray diffraction
3.4Å resolution

Crystal structure of the human beta2 adrenoceptor

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Beta-2 adrenergic receptor Chain: A
Molecule details ›
Chain: A
Length: 365 amino acids
Theoretical weight: 41.28 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P07550 (Residues: 1-365; Coverage: 88%)
Gene names: ADRB2, ADRB2R, B2AR
Sequence domains: 7 transmembrane receptor (rhodopsin family)
Structure domains: Rhopdopsin 7-helix transmembrane proteins
antibody for beta2 adrenoceptor, light chain Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.9 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
antibody for beta2 adrenoceptor, heavy chain Chain: H
Molecule details ›
Chain: H
Length: 217 amino acids
Theoretical weight: 23.24 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: C2
Unit cell:
a: 338.38Å b: 48.48Å c: 89.35Å
α: 90° β: 104.6° γ: 90°
R-values:
R R work R free
0.217 0.217 0.27
Expression system: Not provided