› › Function and Biology

Crystal Structure of the BARD1 BRCT Repeat

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

Quick links

EC 2.3.2.27: RING-type E3 ubiquitin transferase

Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Systematic name:
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein]-L-lysine ubiquitin transferase (isopeptide bond-forming; RING-type)
Alternative Name(s):
  • RING E3 ligase
  • Ubiquitin transferase RING E3

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00533
Domain description: BRCA1 C Terminus (BRCT) domain
Occurring in:
  1. BRCA1-associated RING domain protein 1
The deposited structure of PDB entry 2r1z contains 2 copies of Pfam domain PF00533 (BRCA1 C Terminus (BRCT) domain) in BRCA1-associated RING domain protein 1. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR001357
Domain description: BRCT domain
Occurring in:
  1. BRCA1-associated RING domain protein 1
IPR036420
Domain description: BRCT domain superfamily
Occurring in:
  1. BRCA1-associated RING domain protein 1

Structure domain

CATH CATH domain
3.40.50.10190
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: BRCT domain
Occurring in:
  1. BRCA1-associated RING domain protein 1
The deposited structure of PDB entry 2r1z contains 4 copies of CATH domain 3.40.50.10190 (Rossmann fold) in BRCA1-associated RING domain protein 1. Showing 2 copies in chain B.

Quick links