PDBe 2r0i

X-ray diffraction
2.2Å resolution

Crystal structure of a kinase MARK2/Par-1 mutant

Released:
Source organism: Rattus norvegicus
Entry authors: Panneerselvam S, Marx A, Mandelkow E-M, Mandelkow E

Function and Biology Details

Reactions catalysed:
ATP + a protein = ADP + a phosphoprotein. 
ATP + [tau protein] = ADP + [tau protein] phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase MARK2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 327 amino acids
Theoretical weight: 37.59 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: O08679 (Residues: 39-364; Coverage: 45%)
Gene name: Mark2
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MPG/DESY, HAMBURG BEAMLINE BW6
Spacegroup: P61
Unit cell:
a: 120.405Å b: 120.405Å c: 99.919Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.194 0.192 0.239
Expression system: Escherichia coli