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THE X-RAY STRUCTURE OF A COMPLEX OF 5-N-ACETYL-5-AMINO-3-(1-ETHYLPROPOXY)-1-CYCLOHEXENE-1-CARBOXYLIC ACID (GS4071) AND A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE

Source organism: Influenza A virus
Biochemical function: exo-alpha-sialidase activity
Biological process: viral budding from plasma membrane
Cellular component: virion membrane

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EC 3.2.1.18: Exo-alpha-sialidase

Reaction catalysed:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Systematic name:
Acetylneuraminyl hydrolase
Alternative Name(s):
  • Acetylneuraminidase
  • Alpha-neuraminidase
  • N-acylneuraminate glycohydrolase
  • Neuraminidase
  • Sialidase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00064
Domain description: Neuraminidase
Occurring in:
  1. Neuraminidase
The deposited structure of PDB entry 2qwh contains 1 copy of Pfam domain PF00064 (Neuraminidase) in Neuraminidase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001860
Domain description: Glycoside hydrolase, family 34
Occurring in:
  1. Neuraminidase
IPR036278
Domain description: Sialidase superfamily
Occurring in:
  1. Neuraminidase
IPR033654
Domain description: Sialidase, Influenza viruses A/B
Occurring in:
  1. Neuraminidase

Structure domain

CATH CATH domain
2.120.10.10
Class: Mainly Beta
Architecture: 6 Propeller
Topology: Neuraminidase
Homology: Neuraminidase
Occurring in:
  1. Neuraminidase
The deposited structure of PDB entry 2qwh contains 1 copy of CATH domain 2.120.10.10 (Neuraminidase) in Neuraminidase. Showing 1 copy in chain A.
SCOP SCOP annotation
50940
Class: All beta proteins
Fold: 6-bladed beta-propeller
Superfamily: Sialidases
Occurring in:
  1. Neuraminidase
The deposited structure of PDB entry 2qwh contains 1 copy of SCOP domain 50940 (Sialidases (neuraminidases)) in Neuraminidase. Showing 1 copy in chain A.

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