PDBe 2qw4

X-ray diffraction
2.8Å resolution

Human NR4A1 ligand-binding domain

Released:
Source organism: Homo sapiens
Entry authors: Min JR, Schuetz A, Loppnau P, Weigelt J, Sundstrom M, Arrowsmith CH, Edwards AM, Bochkarev A, Plotnikov AN, Structural Genomics Consortium (SGC)

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear receptor subfamily 4 group A member 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 273 amino acids
Theoretical weight: 30.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P22736 (Residues: 347-598; Coverage: 42%)
Gene names: GFRP1, HMR, NAK1, NR4A1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 89.53Å b: 96.364Å c: 144.849Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.233 0.23 0.292
Expression system: Escherichia coli