› 2qqo

X-ray diffraction
2.3Å resolution

Crystal Structure of the a2b1b2 Domains from Human Neuropilin-2

Released:
DOI: 10.2210/pdb2qqo/pdb
PDB entry 2qqo coloured by chain, front view.
PDB entry 2qqo coloured by chain, side view.
PDB entry 2qqo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding.
Appleton BA, Wu P, Maloney J, Yin J, Liang WC, Stawicki S, Mortara K, Bowman KK, Elliott JM, Desmarais W, Bazan JF, Bagri A, Tessier-Lavigne M, Koch AW, Wu Y, Watts RJ, Wiesmann C
EMBO J 26 4902-12 (2007)
PMID: 17989695

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-129976 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neuropilin-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 460 amino acids
Theoretical weight: 51.94 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: O60462 (Residues: 145-595; Coverage: 50%)
Gene names: NRP2, VEGF165R2
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand CA 2 x CA
Ligand EDO 6 x EDO
Ligand TRS 1 x TRS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P21
Unit cell:
a: 50.093Å b: 192.909Å c: 66.169Å
α: 90° β: 90.08° γ: 90°
R-values:
R R work R free
0.188 0.185 0.239
Expression system: Trichoplusia ni

Quick links

Citations

55 review citations

Role and therapeutic potential of VEGF in the nervous system.
Ruiz de Almodovar et al. (2009)
54 more

4 mentions without citation

Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding.
Appleton et al. (2007)
3 more