PDBe 2qoi

X-ray diffraction
1.25Å resolution

Human EphA3 kinase and juxtamembrane region, Y596F:Y602F double mutant

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ephrin type-A receptor 3 Chain: A
Molecule details ›
Chain: A
Length: 373 amino acids
Theoretical weight: 41.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P29320 (Residues: 577-947; Coverage: 39%)
Gene names: EPHA3, ETK, ETK1, HEK, TYRO4
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 54.134Å b: 38.271Å c: 76.005Å
α: 90° β: 102.41° γ: 90°
R-values:
R R work R free
0.186 0.185 0.192
Expression system: Escherichia coli BL21(DE3)