PDBe 2qoh

X-ray diffraction
1.95Å resolution

Crystal Structure of Abl kinase bound with PPY-A

Released:
Source organism: Mus musculus
Primary publication:
Crystal structure of the T315I mutant of AbI kinase.
Chem Biol Drug Des 70 171-81 (2007)
PMID: 17718712

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase ABL1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 288 amino acids
Theoretical weight: 33.24 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00520 (Residues: 229-515; Coverage: 26%)
Gene names: Abl, Abl1
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P21
Unit cell:
a: 74.008Å b: 59.128Å c: 75.938Å
α: 90° β: 118.39° γ: 90°
R-values:
R R work R free
0.214 0.214 0.255
Expression system: Escherichia coli