PDBe 2qoc

X-ray diffraction
1.25Å resolution

Human EphA3 kinase domain, phosphorylated, AMP-PNP bound structure

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ephrin type-A receptor 3 Chain: A
Molecule details ›
Chain: A
Length: 344 amino acids
Theoretical weight: 38.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P29320 (Residues: 606-947; Coverage: 36%)
Gene names: EPHA3, ETK, ETK1, HEK, TYRO4
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P21
Unit cell:
a: 53.79Å b: 38.337Å c: 76.439Å
α: 90° β: 102.07° γ: 90°
R-values:
R R work R free
0.17 0.169 0.186
Expression system: Escherichia coli BL21(DE3)