PDBe 2qo2

X-ray diffraction
1.6Å resolution

Human EphA3 kinase and juxtamembrane region, dephosphorylated, apo structure

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ephrin type-A receptor 3 Chain: A
Molecule details ›
Chain: A
Length: 373 amino acids
Theoretical weight: 41.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P29320 (Residues: 577-947; Coverage: 39%)
Gene names: EPHA3, ETK, ETK1, HEK, TYRO4
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: P21
Unit cell:
a: 54.449Å b: 38.359Å c: 76.226Å
α: 90° β: 102.63° γ: 90°
R-values:
R R work R free
0.177 0.176 0.203
Expression system: Escherichia coli BL21(DE3)