Assemblies
Multimeric state:
homo dimer
Accessible surface area:
32325.25 Å2
Buried surface area:
5129.03 Å2
Dissociation area:
2,021.3
Å2
Dissociation energy (ΔGdiss):
21.34
kcal/mol
Dissociation entropy (TΔSdiss):
14.33
kcal/mol
Symmetry number:
2
PDBe Complex ID:
PDB-CPX-172220
Macromolecules
Chain: A
Length: 407 amino acids
Theoretical weight: 46.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
Pfam:
Length: 407 amino acids
Theoretical weight: 46.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
- Canonical:
Q15118 (Residues: 30-436; Coverage: 93%)
Pfam:
- Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
- Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
- Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily
- PDK/BCKDK protein kinase
- Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal
- Histidine kinase/HSP90-like ATPase superfamily
- Histidine kinase/HSP90-like ATPase
- Histidine kinase domain
![[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial in PDB entry 2q8h, assembly 1, front view.](https://www.ebi.ac.uk/pdbe/static/entry/2q8h_entity_1_front_image-200x200.png "Homo dimeric assembly 1 of PDB entry <span class='highlight'>2q8h</span> contains 2 copies of <span class='highlight'>[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial</span>. Front view.")
![[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial in PDB entry 2q8h, assembly 1, side view.](https://www.ebi.ac.uk/pdbe/static/entry/2q8h_entity_1_side_image-200x200.png "Homo dimeric assembly 1 of PDB entry <span class='highlight'>2q8h</span> contains 2 copies of <span class='highlight'>[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial</span>. Side view.")
![[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial in PDB entry 2q8h, assembly 1, top view.](https://www.ebi.ac.uk/pdbe/static/entry/2q8h_entity_1_top_image-200x200.png "Homo dimeric assembly 1 of PDB entry <span class='highlight'>2q8h</span> contains 2 copies of <span class='highlight'>[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial</span>. Top view.")