PDBe 2q5a

X-ray diffraction
1.5Å resolution

human Pin1 bound to L-PEPTIDE

Released:

Function and Biology Details

Reaction catalysed:
Peptidylproline (omega=180) = peptidylproline (omega=0). 
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Five residue peptide Chain: B
Molecule details ›
Chain: B
Length: 7 amino acids
Theoretical weight: 807 Da
Source organism: Synthetic construct
Expression system: Not provided
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Chain: A
Molecule details ›
Chain: A
Length: 167 amino acids
Theoretical weight: 18.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13526 (Residues: 1-163; Coverage: 100%)
Gene name: PIN1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:

2 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P3121
Unit cell:
a: 68.842Å b: 68.842Å c: 79.513Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.233 0.232 0.252
Expression systems:
  • Not provided
  • Escherichia coli BL21(DE3)