PDBe 2q3z

X-ray diffraction
2Å resolution

Transglutaminase 2 undergoes large conformational change upon activation


Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Polypeptide Chain: X
Molecule details ›
Chain: X
Length: 7 amino acids
Theoretical weight: 624 Da
Source organism: Synthetic construct
Expression system: Not provided
Protein-glutamine gamma-glutamyltransferase 2 Chain: A
Molecule details ›
Chain: A
Length: 687 amino acids
Theoretical weight: 77.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P21980 (Residues: 1-687; Coverage: 100%)
Gene name: TGM2
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P41212
Unit cell:
a: 71.671Å b: 71.671Å c: 309.01Å
α: 90° β: 90° γ: 90°
R R work R free
0.231 0.228 0.266
Expression systems:
  • Not provided
  • Escherichia coli