PDBe 2q3d

X-ray diffraction
2.2Å resolution

2.2 A Resolution Crystal Structure of O-Acetylserine Sulfhydrylase (OASS) From MYCOBACTERIUM TUBERCULOSIS in Complex with the Reaction Intermediate ALPHA-AMINOACRYLATE

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
O-acetylserine sulfhydrylase Chain: A
Molecule details ›
Chain: A
Length: 313 amino acids
Theoretical weight: 33.07 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P9WP55 (Residues: 1-310; Coverage: 100%)
Gene names: MTCY98.03, Rv2334, cysK, cysK1
Sequence domains: Pyridoxal-phosphate dependent enzyme
Structure domains: Rossmann fold

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-3
Spacegroup: P41212
Unit cell:
a: 71.785Å b: 71.785Å c: 181.179Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.194 0.249
Expression system: Escherichia coli BL21(DE3)