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Crystal structure of an anti-activation complex in bacterial quorum sensing

Source organism: Sinorhizobium fredii NGR234
Biochemical function: protein binding
Biological process: negative regulation of DNA-templated transcription
Cellular component: not assigned

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GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF09228
Domain description: Prokaryotic Transcriptional repressor TraM
Occurring in:
  1. Probable transcriptional repressor TraM
The deposited structure of PDB entry 2q0o contains 2 copies of Pfam domain PF09228 (Prokaryotic Transcriptional repressor TraM) in Probable transcriptional repressor TraM. Showing 1 copy in chain D.

PF00196
Domain description: Bacterial regulatory proteins, luxR family
Occurring in:
  1. Probable transcriptional activator protein TraR
The deposited structure of PDB entry 2q0o contains 2 copies of Pfam domain PF00196 (Bacterial regulatory proteins, luxR family) in Probable transcriptional activator protein TraR. Showing 1 copy in chain A.

PF03472
Domain description: Autoinducer binding domain
Occurring in:
  1. Probable transcriptional activator protein TraR
The deposited structure of PDB entry 2q0o contains 2 copies of Pfam domain PF03472 (Autoinducer binding domain) in Probable transcriptional activator protein TraR. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000792
Domain description: Transcription regulator LuxR, C-terminal
Occurring in:
  1. Probable transcriptional activator protein TraR
IPR036693
Domain description: Transcription factor LuxR-like, autoinducer-binding domain superfamily
Occurring in:
  1. Probable transcriptional activator protein TraR
IPR036336
Domain description: Transcriptional repressor TraM superfamily
Occurring in:
  1. Probable transcriptional repressor TraM
IPR015309
Domain description: Transcriptional repressor TraM
Occurring in:
  1. Probable transcriptional repressor TraM
IPR036388
Domain description: Winged helix-like DNA-binding domain superfamily
Occurring in:
  1. Probable transcriptional activator protein TraR
IPR016032
Domain description: Signal transduction response regulator, C-terminal effector
Occurring in:
  1. Probable transcriptional activator protein TraR
IPR005143
Domain description: Transcription factor LuxR-like, autoinducer-binding domain
Occurring in:
  1. Probable transcriptional activator protein TraR

Structure domains

CATH CATH domains
1.10.287.160
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Helix Hairpins
Homology: HR1 repeat
Occurring in:
  1. Probable transcriptional repressor TraM
The deposited structure of PDB entry 2q0o contains 2 copies of CATH domain 1.10.287.160 (Helix Hairpins) in Probable transcriptional repressor TraM. Showing 1 copy in chain D.
1.10.10.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Arc Repressor Mutant, subunit A
Homology: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Occurring in:
  1. Probable transcriptional activator protein TraR
The deposited structure of PDB entry 2q0o contains 2 copies of CATH domain 1.10.10.10 (Arc Repressor Mutant, subunit A) in Probable transcriptional activator protein TraR. Showing 1 copy in chain A.
3.30.450.80
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Beta-Lactamase
Homology: Transcription factor LuxR-like, autoinducer-binding domain
Occurring in:
  1. Probable transcriptional activator protein TraR
The deposited structure of PDB entry 2q0o contains 2 copies of CATH domain 3.30.450.80 (Beta-Lactamase) in Probable transcriptional activator protein TraR. Showing 1 copy in chain A.

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