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The intrinsic affinity between E2 and the Cys domain of E1 in Ubiquitin-like modifications

Solution NMR
PDB entry 2px9 coloured by chain, ensemble of 20 models, front view.
PDB entry 2px9 coloured by chain, ensemble of 20 models, side view.
PDB entry 2px9 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: SUMO-activating enzyme subunit 2 and SUMO-conjugating enzyme UBC9
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Multimeric state: hetero dimer
Accessible surface area: 19742.39 Å2
Buried surface area: 1410.77 Å2
Dissociation area: 705.38 Å2
Dissociation energy (ΔGdiss): -6.29 kcal/mol
Dissociation entropy (TΔSdiss): 12.2 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-159075

Macromolecules

SUMO-activating enzyme subunit 2
Chain: A
Length: 217 amino acids
Theoretical weight: 24.83 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9UBT2 (Residues: 166-382; Coverage: 34%)
Gene names: HRIHFB2115, SAE2, UBA2, UBLE1B
Pfam: ThiF family
InterPro:
CATH: Ubiquitin activating enzymes (Uba3). Chain: B, domain 2
SUMO-activating enzyme subunit 2 in PDB entry 2px9, assembly 1, front view.
SUMO-activating enzyme subunit 2 in PDB entry 2px9, assembly 1, side view.
SUMO-activating enzyme subunit 2 in PDB entry 2px9, assembly 1, top view.
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SUMO-conjugating enzyme UBC9
Chain: B
Length: 158 amino acids
Theoretical weight: 18.03 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P63279 (Residues: 1-158; Coverage: 100%)
Gene names: UBC9, UBCE9, UBE2I
Pfam: Ubiquitin-conjugating enzyme
InterPro:
CATH: Ubiquitin Conjugating Enzyme
SCOP: UBC-related
SUMO-conjugating enzyme UBC9 in PDB entry 2px9, assembly 1, front view.
SUMO-conjugating enzyme UBC9 in PDB entry 2px9, assembly 1, side view.
SUMO-conjugating enzyme UBC9 in PDB entry 2px9, assembly 1, top view.
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