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Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: biosynthetic process
Cellular component: not assigned

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EC 4.2.1.59: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase

Reaction catalysed:
A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H(2)O
Systematic name:
(3R)-3-hydroxyoctanoyl-[acyl-carrier protein] hydro-lyase (trans-2-enoyl-[acyl-carrier protein]-forming)
Alternative Name(s):
  • (3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase
  • (3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase (oct-2-enoyl-[acyl-carrier protein]-forming)
  • 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase
  • Beta-hydroxyoctanoyl thioester dehydratase
  • Beta-hydroxyoctanoyl-ACP-dehydrase
  • Beta-hydroxyoctanoyl-acyl carrier protein dehydrase
  • D-3-hydroxyoctanoyl-[acyl carrier protein] dehydratase
  • FabA (gene name)
  • FabZ (gene name)

EC 3.1.2.14: Oleoyl-[acyl-carrier-protein] hydrolase

Reaction catalysed:
Oleoyl-[acyl-carrier-protein] + H(2)O = [acyl-carrier-protein] + oleate
Systematic name:
Oleoyl-[acyl-carrier-protein] hydrolase
Alternative Name(s):
  • Acyl-ACP-hydrolase
  • Acyl-[acyl-carrier-protein] hydrolase
  • Acyl-acyl carrier protein hydrolase
  • Oleoyl-ACP thioesterase
  • Oleoyl-acyl carrier protein thioesterase
  • S-acyl fatty acid synthase thioesterase

EC 2.3.1.85: Fatty-acid synthase system

Reaction catalysed:
Acetyl-CoA + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + (n+1) CoA + n CO(2) + 2n NADP(+)
Systematic name:
Acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolyzing)
Alternative Name(s):
  • FASN (gene name)
  • Fatty-acid synthase

EC 2.3.1.41: Beta-ketoacyl-[acyl-carrier-protein] synthase I

Reaction catalysed:
Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein]
Systematic name:
Acyl-[acyl-carrier protein]:malonyl-[acyl-carrier protein] C-acyltransferase (decarboxylating)
Alternative Name(s):
  • 3-ketoacyl-acyl carrier protein synthase
  • 3-oxoacyl-[acyl-carrier-protein] synthase
  • 3-oxoacyl:ACP synthase I
  • Acyl-[acyl-carrier-protein]:malonyl-[acyl-carrier-protein] C-acyltransferase (decarboxylating)
  • Acyl-malonyl acyl carrier protein-condensing enzyme
  • Acyl-malonyl(acyl-carrier-protein)-condensing enzyme
  • Beta-ketoacyl acyl carrier protein synthase
  • Beta-ketoacyl synthetase
  • Beta-ketoacyl-ACP synthase I
  • Beta-ketoacyl-ACP synthetase
  • Beta-ketoacyl-[acyl carrier protein] synthase
  • Beta-ketoacyl-acyl carrier protein synthetase
  • Beta-ketoacylsynthase
  • Condensing enzyme
  • FabB
  • FabF1
  • Fatty acid condensing enzyme
  • KAS I
  • KASI

EC 2.3.1.39: [Acyl-carrier-protein] S-malonyltransferase

Reaction catalysed:
Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein]
Systematic name:
Malonyl-CoA:[acyl-carrier protein] S-malonyltransferase
Alternative Name(s):
  • Acyl carrier protein malonyltransferase
  • FabD
  • MAT
  • MCAT
  • Malonyl coenzyme A-acyl carrier protein transacylase
  • Malonyl transacylase
  • Malonyl transferase
  • Malonyl-CoA-acyl carrier protein transacylase
  • Malonyl-CoA/dephospho-CoA acyltransferase
  • Malonyl-CoA:ACP transacylase
  • Malonyl-CoA:ACP-SH transacylase
  • Malonyl-CoA:AcpM transacylase
  • Malonyl-CoA:[acyl-carrier-protein] S-malonyltransferase
  • Malonyl-CoA:acyl carrier protein transacylase
  • Malonyl-CoA:acyl-carrier-protein transacylase
  • MdcH
  • [Acyl carrier protein]malonyltransferase

EC 2.3.1.38: [Acyl-carrier-protein] S-acetyltransferase

Reaction catalysed:
Acetyl-CoA + [acyl-carrier-protein] = CoA + acetyl-[acyl-carrier-protein]
Systematic name:
Acetyl-CoA:[acyl-carrier-protein] S-acetyltransferase
Alternative Name(s):
  • ACP acetyltransferase
  • Acetyl coenzyme A-acyl-carrier-protein transacylase
  • Acyl-carrier-protein acetyltransferase
  • [ACP]-acetyltransferase
  • [Acyl-carrier protein]-acetyltransferase

EC 1.3.1.39: Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)

Reaction catalysed:
An acyl-[acyl-carrier protein] + NADP(+) = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH
Systematic name:
Acyl-[acyl-carrier protein]:NADP(+) oxidoreductase (Re-specific)
Alternative Name(s):
  • Acyl-ACP dehydrogenase
  • Acyl-[acyl-carrier-protein]:NADP(+) oxidoreductase (A-specific)
  • Acyl-[acyl-carrier-protein]:NADP(+) oxidoreductase (Re-specific)
  • Enoyl-ACp reductase
  • Enoyl-[acyl carrier protein] (reduced nicotinamide adenine dinucleotide phosphate) reductase
  • Enoyl-[acyl-carrier-protein] reductase (NADPH(2), A-specific)
  • Enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific)
  • FabL (gene name)
  • NADPH 2-enoyl Co A reductase

EC 1.1.1.100: 3-oxoacyl-[acyl-carrier-protein] reductase

Reaction catalysed:
(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl-carrier-protein] + NADPH
Systematic name:
(3R)-3-hydroxyacyl-[acyl-carrier-protein]:NADP(+) oxidoreductase
Alternative Name(s):
  • 3-ketoacyl acyl carrier protein reductase
  • 3-oxoacyl-[ACP]reductase
  • Beta-ketoacyl acyl carrier protein (ACP) reductase
  • Beta-ketoacyl reductase
  • Beta-ketoacyl thioester reductase
  • Beta-ketoacyl-ACP reductase
  • Beta-ketoacyl-[acyl-carrier protein](ACP) reductase
  • Beta-ketoacyl-acyl carrier protein reductase
  • NADPH-specific 3-oxoacyl-[acylcarrier protein]reductase

GO terms

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00975
Domain description: Thioesterase domain
Occurring in:
  1. Fatty acid synthase
The deposited structure of PDB entry 2px6 contains 2 copies of Pfam domain PF00975 (Thioesterase domain) in Fatty acid synthase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR029058
Domain description: Alpha/Beta hydrolase fold
Occurring in:
  1. Fatty acid synthase
IPR001031
Domain description: Thioesterase
Occurring in:
  1. Fatty acid synthase

Structure domains

CATH CATH domains
3.40.50.1820
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: alpha/beta hydrolase
Occurring in:
  1. Fatty acid synthase
The deposited structure of PDB entry 2px6 contains 2 copies of CATH domain 3.40.50.1820 (Rossmann fold) in Fatty acid synthase. Showing 1 copy in chain B.
1.10.1470.20
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Protein Yjbj; Chain: A;
Homology: Fatty acid synthase; domain 2
Occurring in:
  1. Fatty acid synthase
The deposited structure of PDB entry 2px6 contains 2 copies of CATH domain 1.10.1470.20 (Protein Yjbj; Chain: A;) in Fatty acid synthase. Showing 1 copy in chain B.

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