PDBe 2pvf

X-ray diffraction
1.8Å resolution

Crystal Structure of Tyrosine Phosphorylated Activated FGF Receptor 2 (FGFR2) Kinase Domain in Complex with ATP Analog and Substrate Peptide

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fibroblast growth factor receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 334 amino acids
Theoretical weight: 38.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P21802 (Residues: 458-778; Coverage: 40%)
Gene names: BEK, FGFR2, KGFR, KSAM
Sequence domains: Protein tyrosine kinase
Structure domains:
Fibroblast growth factor receptor 2 Chain: B
Molecule details ›
Chain: B
Length: 15 amino acids
Theoretical weight: 1.78 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P21802 (Residues: 764-778; Coverage: 2%)
Gene names: BEK, FGFR2, KGFR, KSAM

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P212121
Unit cell:
a: 56.353Å b: 78.436Å c: 84.839Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.251 0.251 0.265
Expression systems:
  • Escherichia coli
  • Not provided