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SYNCHROTRON X-RAY DATA COLLECTION AND RESTRAINED LEAST-SQUARES REFINEMENT OF THE CRYSTAL STRUCTURE OF PROTEINASE K AT 1.5 ANGSTROMS RESOLUTION

Source organism: Parengyodontium album
Biochemical function: serine-type peptidase activity
Biological process: proteolysis
Cellular component: not assigned

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EC 3.4.21.64: Peptidase K

Reaction catalysed:
Hydrolysis of keratin, and of other proteins with subtilisin-like specificity. Hydrolyzes peptide amides.
Systematic name:
-
Alternative Name(s):
  • Endopeptidase K
  • Proteinase K
  • Tritirachium album proteinase K
  • Tritirachium album serine proteinase
  • Tritirachium alkaline proteinase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00082
Domain description: Subtilase family
Occurring in:
  1. Proteinase K
The deposited structure of PDB entry 2prk contains 1 copy of Pfam domain PF00082 (Subtilase family) in Proteinase K. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR015500
Domain description: Peptidase S8, subtilisin-related
Occurring in:
  1. Proteinase K
IPR036852
Domain description: Peptidase S8/S53 domain superfamily
Occurring in:
  1. Proteinase K
IPR023828
Domain description: Peptidase S8, subtilisin, Ser-active site
Occurring in:
  1. Proteinase K
IPR022398
Domain description: Peptidase S8, subtilisin, His-active site
Occurring in:
  1. Proteinase K
IPR023827
Domain description: Peptidase S8, subtilisin, Asp-active site
Occurring in:
  1. Proteinase K
IPR000209
Domain description: Peptidase S8/S53 domain
Occurring in:
  1. Proteinase K
IPR034193
Domain description: Proteinase K-like catalytic domain
Occurring in:
  1. Proteinase K

Structure domain

CATH CATH domain
3.40.50.200
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Peptidase S8/S53 domain
Occurring in:
  1. Proteinase K
The deposited structure of PDB entry 2prk contains 1 copy of CATH domain 3.40.50.200 (Rossmann fold) in Proteinase K. Showing 1 copy in chain A.
SCOP SCOP annotation
52744
Class: Alpha and beta proteins (a/b)
Fold: Subtilisin-like
Superfamily: Subtilisin-like
Occurring in:
  1. Proteinase K
The deposited structure of PDB entry 2prk contains 1 copy of SCOP domain 52744 (Subtilases) in Proteinase K. Showing 1 copy in chain A.

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