PDBe 2pnu

X-ray diffraction
1.65Å resolution

Crystal structure of human androgen receptor ligand-binding domain in complex with EM-5744

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Androgen receptor Chain: A
Molecule details ›
Chain: A
Length: 266 amino acids
Theoretical weight: 31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P10275 (Residues: 655-920; Coverage: 29%)
Gene names: AR, DHTR, NR3C4
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM30A
Spacegroup: P212121
Unit cell:
a: 53.65Å b: 66.36Å c: 70.78Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.183 0.205
Expression system: Escherichia coli BL21(DE3)