PDBe 2ple

Solution NMR

NUCLEAR MAGNETIC RESONANCE STRUCTURE OF AN SH2 DOMAIN OF PHOSPHOLIPASE C-GAMMA1 COMPLEXED WITH A HIGH AFFINITY BINDING PEPTIDE

Released:

Function and Biology Details

Reactions catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. 
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Platelet-derived growth factor receptor beta Chain: B
Molecule details ›
Chain: B
Length: 12 amino acids
Theoretical weight: 1.48 KDa
Source organism: Bos taurus
Expression system: Not provided
UniProt:
  • Canonical: P09619 (Residues: 1018-1029; Coverage: 1%)
Gene names: PDGFR, PDGFR1, PDGFRB
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Chain: A
Molecule details ›
Chain: A
Length: 105 amino acids
Theoretical weight: 12.28 KDa
Source organism: Bos taurus
Expression system: Not provided
UniProt:
  • Canonical: P08487 (Residues: 663-759; Coverage: 8%)
Gene name: PLCG1
Sequence domains: SH2 domain
Structure domains: SHC Adaptor Protein

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
Expression system: Not provided