PDBe 2pl0

X-ray diffraction
2.8Å resolution

LCK bound to imatinib

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase Lck Chain: A
Molecule details ›
Chain: A
Length: 289 amino acids
Theoretical weight: 33.4 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P06239 (Residues: 225-509; Coverage: 56%)
Gene name: LCK
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P21212
Unit cell:
a: 75.21Å b: 103.17Å c: 52.33Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.212 0.261
Expression system: Spodoptera frugiperda