PDBe 2pha

X-ray diffraction
1.9Å resolution

Crystal structure of native, unliganded human arginase at 1.90 resolution

Released:

Function and Biology Details

Reaction catalysed:
L-arginine + H(2)O = L-ornithine + urea. 
Biochemical function:
Cellular component:

Structure analysis Details

Assemblies composition:
homo trimer
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Arginase-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 322 amino acids
Theoretical weight: 34.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05089 (Residues: 1-322; Coverage: 100%)
Gene name: ARG1
Sequence domains: Arginase family
Structure domains: Arginase; Chain A

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12B
Spacegroup: P3
Unit cell:
a: 90.77Å b: 90.77Å c: 69.74Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.198 0.198 0.244
Expression system: Escherichia coli