PDBe 2p7u

X-ray diffraction
1.65Å resolution

The crystal structure of rhodesain, the major cysteine protease of T. brucei rhodesiense, bound to inhibitor K777

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cysteine protease Chain: A
Molecule details ›
Chain: A
Length: 215 amino acids
Theoretical weight: 22.9 KDa
Source organism: Trypanosoma brucei rhodesiense
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q95PM0 (Residues: 126-340; Coverage: 48%)
Gene name: rhodesain
Sequence domains: Papain family cysteine protease
Structure domains: Cysteine proteinases

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P1
Unit cell:
a: 34.377Å b: 39.716Å c: 39.566Å
α: 120.38° β: 93.89° γ: 101.18°
R-values:
R R work R free
0.137 0.135 0.175
Expression system: Komagataella pastoris