PDBe 2p2h

X-ray diffraction
1.95Å resolution

Crystal structure of the VEGFR2 kinase domain in complex with a pyridinyl-triazine inhibitor

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Vascular endothelial growth factor receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 314 amino acids
Theoretical weight: 36.28 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P35968 (Residues: 815-1172; Coverage: 23%)
Gene names: FLK1, KDR, VEGFR2
Structure domains:

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21212
Unit cell:
a: 66.595Å b: 136.915Å c: 58.725Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.205 0.229
Expression system: Trichoplusia ni