PDBe 2oza

X-ray diffraction
2.7Å resolution

Structure of p38alpha complex

Released:
Source organisms:
Primary publication:
Molecular basis of MAPK-activated protein kinase 2:p38 assembly.
Proc. Natl. Acad. Sci. U.S.A. 104 6353-8 (2007)
PMID: 17395714

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Mitogen-activated protein kinase 14 Chain: B
Molecule details ›
Chain: B
Length: 366 amino acids
Theoretical weight: 42.1 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P47811 (Residues: 2-360; Coverage: 100%)
  • Best match: P47811-4 (Residues: 1-283)
Gene names: Crk1, Csbp1, Csbp2, Mapk14
Sequence domains: Protein kinase domain
Structure domains:
MAP kinase-activated protein kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 356 amino acids
Theoretical weight: 40.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P49137 (Residues: 47-400; Coverage: 89%)
Gene name: MAPKAPK2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P41212
Unit cell:
a: 83.31Å b: 83.31Å c: 231.49Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.239 0.239 0.296
Expression system: Escherichia coli BL21(DE3)