PDBe 2oz7

X-ray diffraction
1.8Å resolution

Crystal structure of the human androgen receptor T877A mutant ligand-binding domain with cyproterone acetate


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Androgen receptor Chain: A
Molecule details ›
Chain: A
Length: 249 amino acids
Theoretical weight: 29.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P10275 (Residues: 672-920; Coverage: 27%)
Gene names: AR, DHTR, NR3C4
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P212121
Unit cell:
a: 56.504Å b: 65.82Å c: 71.506Å
α: 90° β: 90° γ: 90°
R R work R free
0.253 0.253 0.27
Expression system: Escherichia coli BL21(DE3)