PDBe 2oz2

X-ray diffraction
1.95Å resolution

Crystal structure analysis of cruzain bound to vinyl sulfone derived inhibitor (K11777)


Function and Biology Details

Reaction catalysed:
Broad endopeptidase specificity similar to that of cathepsin L. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
homo tetramer
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Cruzipain Chains: A, C
Molecule details ›
Chains: A, C
Length: 215 amino acids
Theoretical weight: 22.72 KDa
Source organism: Trypanosoma cruzi
Expression system: Escherichia coli BL21
  • Canonical: P25779 (Residues: 123-337; Coverage: 48%)
Sequence domains: Papain family cysteine protease
Structure domains: Cysteine proteinases

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: C2
Unit cell:
a: 134.346Å b: 37.954Å c: 95.202Å
α: 90° β: 114.34° γ: 90°
R R work R free
0.159 0.157 0.207
Expression system: Escherichia coli BL21