PDBe 2oyu

X-ray diffraction
2.7Å resolution

Indomethacin-(S)-alpha-ethyl-ethanolamide bound to Cyclooxygenase-1

Released:

Function and Biology Details

Reaction catalysed:
Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Prostaglandin G/H synthase 1 Chain: P
Molecule details ›
Chain: P
Length: 600 amino acids
Theoretical weight: 68.85 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: P05979 (Residues: 1-600; Coverage: 100%)
Gene names: COX1, PTGS1
Sequence domains:
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 32-ID
Spacegroup: P6522
Unit cell:
a: 181.41Å b: 181.41Å c: 103.398Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.241 0.241 0.292