PDBe 2owb

X-ray diffraction
2.1Å resolution

Structure of the Catalytic Domain of Human Polo-like Kinase 1

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase PLK1 Chain: A
Molecule details ›
Chain: A
Length: 335 amino acids
Theoretical weight: 37.63 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P53350 (Residues: 13-345; Coverage: 55%)
Gene names: PLK, PLK1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-BM
Spacegroup: P3221
Unit cell:
a: 66.931Å b: 66.931Å c: 153.59Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.205 0.203 0.243
Expression system: Spodoptera frugiperda