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MMP-9 active site mutant with iodine-labeled carboxylate inhibitor

X-ray diffraction
2Å resolution
PDB entry 2ow0 coloured by chain, front view.
PDB entry 2ow0 coloured by chain, side view.
PDB entry 2ow0 coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
monomeric (preferred)
homo tetramer
homo dimer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: 67 kDa matrix metalloproteinase-9
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Multimeric state: monomeric
Accessible surface area: 7896.22 Å2
Buried surface area: 755.7 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-147085
Assembly 2 (preferred)
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Assembly Name: 67 kDa matrix metalloproteinase-9
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Multimeric state: monomeric
Accessible surface area: 7770.62 Å2
Buried surface area: 503.64 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-147085
Assembly 3
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Assembly Name: 67 kDa matrix metalloproteinase-9
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Multimeric state: homo tetramer
Accessible surface area: 26039.56 Å2
Buried surface area: 7805.78 Å2
Dissociation area: 1,190.76 Å2
Dissociation energy (ΔGdiss): 12.94 kcal/mol
Dissociation entropy (TΔSdiss): 11.5 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-147091
Assembly 4
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Assembly Name: 67 kDa matrix metalloproteinase-9
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Multimeric state: homo dimer
Accessible surface area: 14093.44 Å2
Buried surface area: 2833.18 Å2
Dissociation area: 789.81 Å2
Dissociation energy (ΔGdiss): 9.45 kcal/mol
Dissociation entropy (TΔSdiss): 11.93 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-147089
Assembly 5
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Assembly Name: 67 kDa matrix metalloproteinase-9
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Multimeric state: homo dimer
Accessible surface area: 14593.6 Å2
Buried surface area: 2332.59 Å2
Dissociation area: 595.94 Å2
Dissociation energy (ΔGdiss): 1.56 kcal/mol
Dissociation entropy (TΔSdiss): 10.68 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-147089

Macromolecules

67 kDa matrix metalloproteinase-9
Chains: A, B
Length: 159 amino acids
Theoretical weight: 17.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P14780 (Residues: 110-443; Coverage: 23%)
Gene names: CLG4B, MMP9
Pfam: Matrixin
InterPro:
CATH: Collagenase (Catalytic Domain)
SCOP: Matrix metalloproteases, catalytic domain
67 kDa matrix metalloproteinase-9 in PDB entry 2ow0, assembly 2, front view.
67 kDa matrix metalloproteinase-9 in PDB entry 2ow0, assembly 2, side view.
67 kDa matrix metalloproteinase-9 in PDB entry 2ow0, assembly 2, top view.
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