PDBe 2ovh

X-ray diffraction
2Å resolution

Progesterone Receptor with Bound Asoprisnil and a Peptide from the Co-Repressor SMRT

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
SMRT peptide Chain: B
Molecule details ›
Chain: B
Length: 17 amino acids
Theoretical weight: 1.91 KDa
Source organism: Synthetic construct
Expression system: Not provided
Progesterone receptor Chain: A
Molecule details ›
Chain: A
Length: 256 amino acids
Theoretical weight: 29.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P06401 (Residues: 678-933; Coverage: 27%)
Gene names: NR3C3, PGR
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P3221
Unit cell:
a: 87.475Å b: 87.475Å c: 90.599Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.2 0.198 0.222
Expression systems:
  • Not provided
  • Escherichia coli BL21(DE3)