PDBe 2ouz

X-ray diffraction
2Å resolution

Crystal Structure of Estrogen Receptor alpha-lasofoxifene complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Estrogen receptor Chain: A
Molecule details ›
Chain: A
Length: 253 amino acids
Theoretical weight: 28.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P03372 (Residues: 301-553; Coverage: 43%)
Gene names: ESR, ESR1, NR3A1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200H
Spacegroup: P6522
Unit cell:
a: 58.306Å b: 58.306Å c: 275.033Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.202 0.199 0.269
Expression system: Escherichia coli