PDBe 2orv

X-ray diffraction
2.3Å resolution

human Thymidine Kinase 1 in complex with TP4A

Released:

Function and Biology Details

Reaction catalysed:
ATP + thymidine = ADP + thymidine 5'-phosphate. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assemblies composition:
homo tetramer
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thymidine kinase, cytosolic Chains: A, B
Molecule details ›
Chains: A, B
Length: 234 amino acids
Theoretical weight: 25.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04183 (Residues: 1-234; Coverage: 100%)
Gene name: TK1
Sequence domains: Thymidine kinase
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P3121
Unit cell:
a: 80.98Å b: 80.98Å c: 156.36Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.202 0.197 0.249
Expression system: Escherichia coli