Structure analysis

Tandem SH2 domains of ZAP-70 with 19-mer zeta1 peptide

X-ray diffraction
1.9Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 13900 Å2
Buried surface area: 2500 Å2
Dissociation area: 1,200 Å2
Dissociation energy (ΔGdiss): 14 kcal/mol
Dissociation entropy (TΔSdiss): 10 kcal/mol
Interface energy (ΔGint): -13 kcal/mol
Symmetry number: 1

Macromolecules

Chain: A
Length: 254 amino acids
Theoretical weight: 28.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P43403 (Residues: 3-256; Coverage: 41%)
Gene names: SRK, ZAP70
Pfam: SH2 domain
InterPro:
CATH:
SCOP: SH2 domain

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Chain: B
Length: 19 amino acids
Theoretical weight: 2.52 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P20963 (Residues: 69-87; Coverage: 13%)
Gene names: CD247, CD3Z, T3Z, TCRZ
InterPro: Phosphorylated immunoreceptor signalling ITAM

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