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Crystal Structure of the Human Receptor Phosphatase PTPRT

X-ray diffraction
1.8Å resolution
PDB entry 2ooq coloured by chain, front view.
PDB entry 2ooq coloured by chain, side view.
PDB entry 2ooq coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Receptor-type tyrosine-protein phosphatase T
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Multimeric state: monomeric
Accessible surface area: 12320.38 Å2
Buried surface area: 331.7 Å2
Dissociation area: 165.85 Å2
Dissociation energy (ΔGdiss): -3 kcal/mol
Dissociation entropy (TΔSdiss): 2.4 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-126994
Assembly 2 (preferred)
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Assembly Name: Receptor-type tyrosine-protein phosphatase T
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Multimeric state: monomeric
Accessible surface area: 12826.52 Å2
Buried surface area: 716.98 Å2
Dissociation area: 101.31 Å2
Dissociation energy (ΔGdiss): -3.15 kcal/mol
Dissociation entropy (TΔSdiss): -0.31 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-126994

Macromolecules

Receptor-type tyrosine-protein phosphatase T
Chains: A, B
Length: 286 amino acids
Theoretical weight: 32.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14522 (Residues: 868-1151; Coverage: 20%)
Gene names: KIAA0283, PTPRT
Pfam: Protein-tyrosine phosphatase
InterPro:
CATH: Protein tyrosine phosphatase superfamily
Receptor-type tyrosine-protein phosphatase T in PDB entry 2ooq, assembly 2, front view.
Receptor-type tyrosine-protein phosphatase T in PDB entry 2ooq, assembly 2, side view.
Receptor-type tyrosine-protein phosphatase T in PDB entry 2ooq, assembly 2, top view.
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