PDBe 2ooq

X-ray diffraction
1.8Å resolution

Crystal Structure of the Human Receptor Phosphatase PTPRT

Released:

Function and Biology Details

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. 
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor-type tyrosine-protein phosphatase T Chains: A, B
Molecule details ›
Chains: A, B
Length: 286 amino acids
Theoretical weight: 32.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14522 (Residues: 868-1151; Coverage: 20%)
Gene names: KIAA0283, PTPRT
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200HB
Spacegroup: P21
Unit cell:
a: 37.186Å b: 86.697Å c: 91.12Å
α: 90° β: 99.89° γ: 90°
R-values:
R R work R free
0.147 0.145 0.188
Expression system: Escherichia coli