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Structure of LNR-HD (Negative Regulatory Region) from human Notch 2

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: cell differentiation
Cellular component: membrane

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GO terms

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00066
Domain description: LNR domain
Occurring in:
  1. Notch 2 extracellular truncation
The deposited structure of PDB entry 2oo4 contains 6 copies of Pfam domain PF00066 (LNR domain) in Notch 2 extracellular truncation. Showing 3 copies in chain A.

PF07684
Domain description: NOTCH protein
Occurring in:
  1. Notch 2 extracellular truncation
The deposited structure of PDB entry 2oo4 contains 2 copies of Pfam domain PF07684 (NOTCH protein) in Notch 2 extracellular truncation. Showing 1 copy in chain A.

PF06816
Domain description: NOTCH protein
Occurring in:
  1. Notch 2 extracellular truncation
The deposited structure of PDB entry 2oo4 contains 2 copies of Pfam domain PF06816 (NOTCH protein) in Notch 2 extracellular truncation. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000800
Domain description: Notch domain
Occurring in:
  1. Notch 2 extracellular truncation
IPR035993
Domain description: Notch-like domain superfamily
Occurring in:
  1. Notch 2 extracellular truncation
IPR011656
Domain description: Notch, NODP domain
Occurring in:
  1. Notch 2 extracellular truncation
IPR010660
Domain description: Notch, NOD domain
Occurring in:
  1. Notch 2 extracellular truncation

Structure domains

CATH CATH domains
3.30.70.3310
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Alpha-Beta Plaits
Occurring in:
  1. Notch 2 extracellular truncation
The deposited structure of PDB entry 2oo4 contains 2 copies of CATH domain 3.30.70.3310 (Alpha-Beta Plaits) in Notch 2 extracellular truncation. Showing 1 copy in chain A.
3.30.300.320
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: GMP Synthetase; Chain A, domain 3
Homology: GMP Synthetase; Chain A, domain 3
Occurring in:
  1. Notch 2 extracellular truncation
The deposited structure of PDB entry 2oo4 contains 2 copies of CATH domain 3.30.300.320 (GMP Synthetase; Chain A, domain 3) in Notch 2 extracellular truncation. Showing 1 copy in chain A.

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