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Structure of LNR-HD (Negative Regulatory Region) from human Notch 2

X-ray diffraction
2.003Å resolution
PDB entry 2oo4 coloured by chain, front view.
PDB entry 2oo4 coloured by chain, side view.
PDB entry 2oo4 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Notch 2 extracellular truncation
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Multimeric state: monomeric
Accessible surface area: 11648.5 Å2
Buried surface area: 1730.31 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-170057
Assembly 2
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Assembly Name: Notch 2 extracellular truncation
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Multimeric state: monomeric
Accessible surface area: 11571.14 Å2
Buried surface area: 274.17 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-170057

Macromolecules

Notch 2 extracellular truncation
Chains: A, B
Length: 234 amino acids
Theoretical weight: 25.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q04721 (Residues: 1423-1677; Coverage: 10%)
Gene name: NOTCH2
Pfam:
InterPro:
CATH:
Notch 2 extracellular truncation in PDB entry 2oo4, assembly 1, front view.
Notch 2 extracellular truncation in PDB entry 2oo4, assembly 1, side view.
Notch 2 extracellular truncation in PDB entry 2oo4, assembly 1, top view.
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