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Crystal Structure of the p38a-MAPKAP kinase 2 Heterodimer

Source organism: Homo sapiens
Biochemical function: protein serine kinase activity
Biological process: 3'-UTR-mediated mRNA stabilization
Cellular component: cytosol

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EC 2.7.11.1: Non-specific serine/threonine protein kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (non-specific)
Alternative Name(s):
  • A-kinase
  • AP50 kinase
  • ATP-protein transphosphorylase
  • Beta-IIPKC
  • Beta-adrenergic receptor kinase
  • CK-2
  • CKI
  • CKII
  • Calcium-dependent protein kinase C
  • Calcium/phospholipid-dependent protein kinase
  • Casein kinase
  • Casein kinase (phosphorylating)
  • Casein kinase 2
  • Casein kinase I
  • Casein kinase II
  • Cyclic AMP-dependent protein kinase
  • Cyclic AMP-dependent protein kinase A
  • Cyclic monophosphate-dependent protein kinase
  • Cyclic nucleotide-dependent protein kinase
  • Cyclin-dependent kinase
  • Cytidine 3',5'-cyclic monophosphate-responsive protein kinase
  • Dsk1
  • Epsilon PKC
  • Glycogen synthase A kinase
  • Glycogen synthase a kinase
  • Glycogen synthase kinase
  • HIPK2
  • Hpr kinase
  • Hydroxyalkyl-protein kinase
  • M phase-specific cdc2 kinase
  • MAPK
  • Mitogen-activated S6 kinase
  • Mitogen-activated protein kinase
  • P82 kinase
  • PKA
  • PKC
  • Phosphorylase B kinase kinase
  • Phosphorylase b kinase kinase
  • Phosphorylase b kinase kinase
  • Protein glutamyl kinase
  • Protein kinase (phosphorylating)
  • Protein kinase A
  • Protein kinase CK2
  • Protein kinase p58
  • Protein phosphokinase
  • Protein serine kinase
  • Protein serine-threonine kinase
  • Protein-aspartyl kinase
  • Protein-cysteine kinase
  • Protein-serine kinase
  • Prp4 protein kinase
  • Raf kinase
  • Raf-1
  • Ribosomal S6 protein kinase
  • Ribosomal protein S6 kinase II
  • STK32
  • Serine kinase
  • Serine protein kinase
  • Serine(threonine) protein kinase
  • Serine-specific protein kinase
  • Serine/threonine protein kinase
  • T-antigen kinase
  • Threonine-specific protein kinase
  • Twitchin kinase
  • Type-2 casein kinase
  • WEE1Hu
  • Wee 1-like kinase
  • Wee-kinase
  • cAMP-dependent protein kinase
  • cAMP-dependent protein kinase A
  • cGMP-dependent protein kinase

EC 2.7.11.24: Mitogen-activated protein kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (MAPKK-activated)
Alternative Name(s):
  • C-Jun N-terminal kinase
  • Dp38
  • ERK
  • ERK1
  • ERK2
  • Extracellular signal-regulated kinase
  • JNK
  • JNK3-alpha-1
  • LeMPK3
  • MAP kinase
  • MAP-2 kinase
  • MAPK
  • MBP kinase I
  • MBP kinase II
  • Microtubule-associated protein 2 kinase
  • Microtubule-associated protein kinase
  • Myelin basic protein kinase
  • P38-2
  • P38-delta
  • P42 mitogen-activated protein kinase
  • P42(mapk)
  • P44mpk
  • PMK-1
  • PMK-2
  • PMK-3
  • Pp42
  • Pp44(mapk)
  • SAPK
  • STK26
  • Stress-activated protein kinase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00069
Domain description: Protein kinase domain
Occurring in:
  1. Mitogen-activated protein kinase 14
  2. MAP kinase-activated protein kinase 2
The deposited structure of PDB entry 2onl contains 2 copies of Pfam domain PF00069 (Protein kinase domain) in Mitogen-activated protein kinase 14. Showing 1 copy in chain C [auth B].
The deposited structure of PDB entry 2onl contains 2 copies of Pfam domain PF00069 (Protein kinase domain) in MAP kinase-activated protein kinase 2. Showing 1 copy in chain B [auth C].

InterPro InterPro annotations
IPR008352
Domain description: Mitogen-activated protein (MAP) kinase p38-like
Occurring in:
  1. Mitogen-activated protein kinase 14
IPR000719
Domain description: Protein kinase domain
Occurring in:
  1. Mitogen-activated protein kinase 14
  2. MAP kinase-activated protein kinase 2
IPR017441
Domain description: Protein kinase, ATP binding site
Occurring in:
  1. Mitogen-activated protein kinase 14
  2. MAP kinase-activated protein kinase 2
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. Mitogen-activated protein kinase 14
  2. MAP kinase-activated protein kinase 2
IPR027442
Domain description: MAP kinase activated protein kinase, C-terminal
Occurring in:
  1. MAP kinase-activated protein kinase 2
IPR008271
Domain description: Serine/threonine-protein kinase, active site
Occurring in:
  1. MAP kinase-activated protein kinase 2
IPR003527
Domain description: Mitogen-activated protein (MAP) kinase, conserved site
Occurring in:
  1. Mitogen-activated protein kinase 14
IPR038784
Domain description: Mitogen-activated protein kinase 14
Occurring in:
  1. Mitogen-activated protein kinase 14

Structure domains

CATH CATH domains
3.30.200.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Phosphorylase Kinase; domain 1
Homology: Phosphorylase Kinase; domain 1
Occurring in:
  1. Mitogen-activated protein kinase 14
  2. MAP kinase-activated protein kinase 2
The deposited structure of PDB entry 2onl contains 2 copies of CATH domain 3.30.200.20 (Phosphorylase Kinase; domain 1) in Mitogen-activated protein kinase 14. Showing 1 copy in chain C [auth B].
The deposited structure of PDB entry 2onl contains 2 copies of CATH domain 3.30.200.20 (Phosphorylase Kinase; domain 1) in MAP kinase-activated protein kinase 2. Showing 1 copy in chain B [auth C].
1.10.510.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Transferase(Phosphotransferase); domain 1
Homology: Transferase(Phosphotransferase) domain 1
Occurring in:
  1. Mitogen-activated protein kinase 14
  2. MAP kinase-activated protein kinase 2
The deposited structure of PDB entry 2onl contains 2 copies of CATH domain 1.10.510.10 (Transferase(Phosphotransferase); domain 1) in Mitogen-activated protein kinase 14. Showing 1 copy in chain C [auth B].
The deposited structure of PDB entry 2onl contains 2 copies of CATH domain 1.10.510.10 (Transferase(Phosphotransferase); domain 1) in MAP kinase-activated protein kinase 2. Showing 1 copy in chain B [auth C].
4.10.1170.10
Class: Few Secondary Structures
Architecture: Irregular
Topology: Protein kinase-like (PK-like)
Homology: MAP kinase activated protein kinase 2
Occurring in:
  1. MAP kinase-activated protein kinase 2
The deposited structure of PDB entry 2onl contains 2 copies of CATH domain 4.10.1170.10 (Protein kinase-like (PK-like)) in MAP kinase-activated protein kinase 2. Showing 1 copy in chain B [auth C].
SCOP SCOP annotation
88854
Class: Alpha and beta proteins (a+b)
Fold: Protein kinase-like (PK-like)
Superfamily: Protein kinase-like (PK-like)
Occurring in:
  1. Mitogen-activated protein kinase 14
  2. MAP kinase-activated protein kinase 2
The deposited structure of PDB entry 2onl contains 2 copies of SCOP domain 88854 (Protein kinases, catalytic subunit) in Mitogen-activated protein kinase 14. Showing 1 copy in chain C [auth B].
The deposited structure of PDB entry 2onl contains 2 copies of SCOP domain 88854 (Protein kinases, catalytic subunit) in MAP kinase-activated protein kinase 2. Showing 1 copy in chain B [auth C].

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